END3 — Magnaporthe oryzae 70-15

Summary

MGG_06180 (END3, MoEND3) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a protein containing EF-hand and EH domains, with molecular functions including actin binding, calcium ion binding, and protein binding/bridging. The gene is associated with endocytosis, receptor internalization, endosomal transport, appressorium formation, actin filament organization, autophagy, secretion, signal transduction, protein phosphorylation, and the DNA damage response. It localizes to the endosome membrane, actin patch, plasmalemma, and cytoplasm. Phenotypic associations include abnormal filamentous growth, decreased endocytosis rate, altered cell cycle progression, abnormal autophagy and pexophagy, decreased pheromone sensitivity, and abnormal spore wall formation. The gene has been linked to barley and rice blast disease. Studies of related genes in other species connect the family to additional processes such as vacuolar transport and ionizing radiation resistance.