PRS — Magnaporthe oryzae 70-15

Summary

MoPRS (MGG_06345) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a proline-tRNA ligase (EC 6.1.1.15) with prolyl-tRNA aminoacylation activity and ATP binding, belonging to the Pro-tRNA-synth_IIa family. The protein localizes to the mitochondrial lumen and is associated with mitochondrial translation, the MAPK cascade, phytoalexin biosynthesis, and ethylene anabolism. The gene is linked to abnormal RNA localization and nucleolar morphology, increased nucleolar size, increased filamentous growth, heat sensitivity, inviability, haploinsufficiency, decreased vegetative growth and competitive fitness, and decreased chemical resistance. Studies of related genes in other species connect the family to abnormal mitochondrial genome maintenance, increased mutation frequency, altered stress and metal resistance, decreased chronological lifespan, and abnormal carbon and nitrogen source utilization.