TRP1 — Magnaporthe oryzae 70-15

Summary

MoTRP1 (MGG_06425) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein with anthranilate synthase, phosphoribosylanthranilate isomerase, and indole-3-glycerol-phosphate synthase activities (EC 4.1.3.27, 5.3.1.24, 4.1.1.48). The gene is associated with tryptophan formation, appressorium formation, invasive growth, sporulation, hyphal growth, and DNA repair. It localises to the anthranilate synthase complex and cytosol. Phenotypic associations include decreased sporulation, absent invasive growth, decreased filamentous growth, decreased cell size, altered cell cycle progression, increased chronological lifespan, and altered stress responses (e.g., decreased UV, gamma ray, ionic stress, and freeze-thaw resistance, but increased innate thermotolerance and stress resistance). Studies of related genes in other species link the family to oxidative stress response, nitrogen source utilisation, and alkaline pH resistance.