HSP98 — Magnaporthe oryzae 70-15

Summary

MGG_06459 (symbol HSP98, preferred name MoHSP98) in Magnaporthe oryzae 70-15 on chromosome 4 encodes an Hsp98-like protein with ATP-dependent protein disaggregase activity, misfolded protein binding, chaperone protein binding, and ATP hydrolase activity. It is associated with cellular response to misfolded protein, cellular thermotolerance, protein stabilization, unfolding, and refolding, as well as appressorium formation, flocculation, invasive growth, MAPK cascade, dephosphorylation, autophagy, and stress response. The gene is linked to abnormal prion inheritance, biofilm formation, cell fusion, and nitrogen source utilization, with normal vegetative growth and acquired thermotolerance. It localizes to the cytoplasm, cytosol, nucleus, nuclear envelope, protein aggregate center, and mitochondrial lumen. Related genes in other species connect the family to oxidative stress response.