UBA2 — Magnaporthe oryzae 70-15

Summary

MoUBA2 (MGG_06733) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a ubiquitin-activating enzyme E1-like protein with adenylyltransferase, ubiquitin-activating, SUMO-conjugating, URM1-activating, RUB1-activating, and molybdopterin-synthase sulfurtransferase activities. The gene is associated with protein ubiquitination, sumoylation, neddylation, urmylation, and molybdenum cofactor biosynthesis. It is linked to appressorium formation, regulation of pseudohyphal growth, invasive growth in response to glucose limitation, cellular response to oxidative stress, DNA damage response, DNA repair, cell cycle, and chromosome segregation. Associations also include altered budding patterns, cell size abnormalities, increased fermentative growth, and decreased mutation frequency. The protein localizes to the cytoplasm, cytosol, and nucleus. Related genes in other species link it to cell cycle control and DNA repair pathways.