ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_06878) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an ABC-type transporter with ATP hydrolase activity, belonging to the type 1 exporter family and containing AAA+ ATPase and P-loop NTPase domains. The gene is associated with xenobiotic detoxification via transmembrane export across the plasma membrane, oligopeptide export from the mitochondrion, and response to antibiotics and toxic substances. It has been linked to host invasion, invasive growth, morphogenesis, cell wall biogenesis, autophagy, secondary metabolism, and siRNA-mediated post-transcriptional gene silencing. Localisation evidence connects the product to the fungal vacuole, mitochondrial inner membrane, and plasma membrane. Phenotypic associations include altered vacuolar morphology, decreased endocytosis, abnormal cell cycle progression, increased entry into G0, and reduced hyperosmotic and hypoosmotic stress resistance.