GDI1 — Magnaporthe oryzae 70-15

Summary

MGG_07137 (GDI1, MoGDI1) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a Rab GDP dissociation inhibitor (RabGDI) with Rab GDP-dissociation inhibitor activity, small GTPase binding, and GGTaseII and GAP activities. The gene is associated with small GTPase-mediated signal transduction, protein membrane targeting, vesicle transport, and ER-to-Golgi transport. Its product localises to the membrane, cytoplasm, cytosol, nucleus, cell division site, and GGTase-II complex. MoGDI1 is linked to abnormal Golgi and ER distribution, delayed endocytosis and protein transport, decreased cell cycle progression and meiosis, increased ionic stress resistance, abnormal spore wall formation, chitin deposition, and bud neck morphology, as well as altered pheromone production and sensitivity. Studies of related genes in other species connect the family to YIP1 and PMR1.