TIF — Magnaporthe oryzae 70-15

Summary

MGG_07333 (TIF, also known as DBP5, FAL1, MoFAL1, MoDBP5, TIF1, TIF2, MoTIF1, MoTIF2, MoTIF) in Magnaporthe oryzae 70-15 encodes a DEAD/DEAH box RNA helicase with ATP hydrolase, RNA helicase, mRNA binding, RNA binding, and inositol hexakisphosphate (IP6) binding activities. The gene is associated with mRNA and tRNA nuclear export, translation termination, homologous recombination, hyphal growth, protein transport, signal transduction, and defense and immune responses. It localizes to the nucleus, cytoplasm, nuclear pore complex, stress granules, and cellular bud tips. Associations with abnormal chemical compound excretion, increased vacuolar transport, decreased RNA localization, absent peroxisomal transport and apoptosis, premature cell cycle progression, and delayed exit from stationary phase have been noted. Studies of related genes in other species link the family to protein content.