DBP2 — Magnaporthe oryzae 70-15

Summary

MGG_07718 (DBP2, also known as DRS1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a DEAD-box RNA helicase with ATP hydrolase and RNA binding activities. The gene is associated with ribosomal large subunit assembly, ribosome biogenesis, rRNA processing, and gene expression, and its product localises to the nucleolus, preribosome large subunit precursor, and cytosol. DBP2 is associated with sexual reproduction, mating, and digestion. Phenotypic associations include abnormal mitotic recombination, decreased mating-type switching, absent sporulation efficiency, delayed vegetative and exponential-phase growth, increased thermotolerance and gamma ray resistance, altered cell cycle progression (including premature G1/S transition and delayed anaphase), increased fermentative growth, and altered carbon source utilisation. Studies of related genes in other species connect the family to oxidative stress response.