TAS1 — Magnaporthe oryzae 70-15

Summary

MGG_07803 (TAS1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a multi-domain protein with ketoacyl-ACP synthase, ligase, methyltransferase and redox activities, and is annotated as a fatty acid synthase. The protein contains domains characteristic of a polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) hybrid, including acyl carrier protein, condensation, and adenylation domains. TAS1 is associated with the biosynthesis of secondary metabolites, including mycotoxins, and with the regulation of secondary metabolism, fatty acid biosynthesis, and membrane transport. The gene product localises to the cytoplasm and is linked to small molecule metabolism and methylation. Studies of related genes in other species connect the TAS1 family to secondary metabolite production. TAS1 is also associated with blast disease in rice (Oryza sativa).