FMA1 — Magnaporthe oryzae 70-15

Summary

MGG_08139 (FMA1) in Magnaporthe oryzae 70-15 on chromosome 2 encodes an initiator methionyl aminopeptidase (EC 3.4.11.18) with metalloaminopeptidase activity and zinc binding, belonging to the Pept_M24 family and containing a Znf-C6H2 domain. The gene is associated with appressorium formation, protein processing, and proteolysis, and localises to the nucleolus and cytosol. Phenotypic associations include decreased growth in exponential phase, abnormal spindle morphology and actin cytoskeleton, increased nucleolus size, decreased sporulation, altered cell cycle progression (decreased G2 duration, telophase arrest), increased replicative lifespan, decreased freeze-thaw and ionic stress resistance, increased innate thermotolerance, and abnormal colony appearance. Studies of related genes in other species link the family to oxidative stress response, decreased colony size, and altered budding pattern.