RAB7 — Magnaporthe oryzae 70-15

Summary

MoRAB7 (MGG_08144) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a small GTPase with GTPase activity and GTP binding. The gene is associated with numerous cellular processes including vacuole fusion, autophagy, endosome organization, mitotic cytokinesis, appressorium formation, and responses to carbon starvation, salt, and osmotic stress. It localizes to late endosomes, the cleavage furrow leading edge, growing cell tips, and meiotic spindle pole bodies. Associations with traits include altered vacuolar morphology, decreased oxidative phosphorylation, increased hydrostatic pressure resistance, delayed endocytosis and protein transport, abnormal cell cycle and budding, and increased entry into stationary phase. The gene is also linked to blast disease in rice and barley. Studies of related genes in other species connect the family to zinc and calcium sensitivity, phosphate content, and oxidative stress response.