NDK1 — Magnaporthe oryzae 70-15

Summary

MoNDK1 (MGG_08622) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a nucleoside diphosphate kinase (EC 2.7.4.6) with nucleoside diphosphate kinase activity, ATP binding, and metal binding. The gene is associated with nucleoside triphosphate, UTP, CTP, and GTP anabolism, as well as anisotropic cell growth, metabolic burst, innate immunity, appressorium formation, hyphal growth, DNA damage response, and homeostasis. It localises to the mitochondrial envelope lumen, extracellular space, cytosol, and nucleus. Phenotypic associations include abnormal mitochondrial and lipid particle morphology, increased mutation frequency and colony sectoring, increased cold and heat sensitivity, decreased respiratory growth and starvation resistance, altered protein accumulation, and increased killer toxin resistance. Related genes in other species link the family to mitochondrial transport and vegetative growth.