pkcA — Magnaporthe oryzae 70-15

Summary

MGG_08689 (pkcA) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a protein kinase C-like enzyme with novel protein kinase C activity (EC 2.7.11.13), protein serine/threonine kinase activity, lipid binding, zinc binding and ATP binding. It contains C2, HR1, C1-like and protein kinase domains. The gene is associated with positive regulation of the cell integrity MAPK cascade, regulation of cell shape, actin cytoskeleton organization, fungal-type cell wall biogenesis and melanin anabolism. It is linked to cellular bud neck septin ring organization, regulation of mitotic cytokinesis site selection, and positive regulation of cytoplasmic mRNA processing body assembly. The product localizes to the actomyosin contractile ring, division septum, site of polarized growth, cell tip, cell cortex of cell tip, stress granule and cytoskeleton. Related genes in other species are linked to reduced virulence.