FBP1 — Magnaporthe oryzae 70-15

Summary

MGG_08895 (MoFBP1, FBP1) in Magnaporthe oryzae 70-15 on chromosome 2 encodes a fructose-1,6-bisphosphatase (EC 3.1.3.11), a class-1 FBPase with N-terminal and C-terminal domains that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. The gene is associated with gluconeogenesis, carbohydrate metabolism, sucrose anabolism, and cellular response to glucose starvation, as well as invasive growth, sporulation, and protein modification. MoFBP1 localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal colony shape, increased entry into G0, increased respiratory metabolism, decreased nitrogen source utilization, and altered responses to alkaline pH, UV, and oxidative stress. Studies of related genes in other species link the FBPase family to oxidative stress response.