ERV29 — Magnaporthe oryzae 70-15

Summary

MoERV29 (MGG_09309) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an ER-derived vesicles protein ERV29 with COPII receptor activity, belonging to the Surf4/Surf1 family. The gene is associated with ER-to-Golgi transport, Golgi organization, secretion, appressorium formation, spore germination, and hyphal growth, and localizes to the ER membrane, COPII-coated vesicles, Golgi complex, and VTC. It has been linked to numerous phenotypes including increased thermotolerance, increased lifespan, increased autophagy, decreased protein secretion, abnormal cell wall morphology, decreased viability, and altered cell cycle progression, as well as abnormal ER, mitochondrial, nuclear, and lipid particle morphology. Studies of related genes in other species connect the family to abnormal sporulation, decreased anaerobic growth, and decreased starvation resistance.