CLM2 — Magnaporthe oryzae 70-15

Summary

MGG_09380 (MoCLM2) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a cytochrome P450 monooxygenase with heme and iron binding, oxidoreductase activity acting on paired donors with incorporation of molecular oxygen, and a Cyt_P450_E_grp-IV domain. The gene is associated with ergosterol and terpenoid anabolism, demethylation, secondary metabolite biosynthesis, mycotoxin anabolism, sporulation, hyphal growth, and mitophagy. It is linked to decreased micronucleophagy, nucleophagy, and ribophagy; abnormal plasma membrane morphology and cell cycle progression; increased cell death; and arrested vegetative and exponential-phase growth. The product localises to the membrane. Studies of related genes in other species connect the family to sterol biosynthesis and protein content.