LAP2 — Magnaporthe oryzae 70-15

Summary

MGG_09481 (MoLAP2) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a protein with aminopeptidase activity, epoxide hydrolase activity, leukotriene-A4 hydrolase activity, metallopeptidase activity, and zinc binding, belonging to the peptidase M1 family. The gene is associated with autophagic cell death, autophagy, the cytoplasm-to-vacuole targeting (NVT) pathway, appressorium formation, cytokinesis, cell cycle, secretion, detoxification, lipid transport and metabolism, protein and peptide breakdown, and proteolysis. Its product localises to the cytosol, nucleus, fungal-type vacuole lumen, and multivesicular bodies (MVBs). Related genes in other species link the family to oxidative stress response, altered vegetative growth, abnormal vacuolar morphology, and changes in thermotolerance and chemical resistance.