GET3 — Magnaporthe oryzae 70-15

Summary

MGG_09535 (GET3, MoGET3) on chromosome 3 of Magnaporthe oryzae 70-15 encodes an ATP hydrolase (EC 3.6.-.-) with ATP and metal binding and identical protein binding activities, belonging to the ArsA/GET3 ATPase family. The gene is associated with type II transmembrane protein insertion into the ER membrane, the GET complex, asexual reproduction, hyphal growth, osmotic response, and ER stress response. It has been linked to numerous phenotypes including abnormal colony shape, absent filamentous growth, decreased cell fusion, altered pheromone sensitivity and mating response, defective nuclear import and fusion, impaired meiosis and mitotic cell cycle progression, aberrant protein secretion, altered respiratory metabolism, increased starvation resistance, and decreased iron utilization. Studies of related genes in other species connect the family to reduced virulence.