MNR2 — Magnaporthe oryzae 70-15

Summary

MGG_09884, designated MoMNR2 on chromosome 1 of Magnaporthe oryzae 70-15, encodes a manganese resistance protein MNR2 belonging to the Alr1-like and CorA family of metal ion transporters. The protein possesses magnesium ion transmembrane transporter activity and is associated with cellular magnesium ion homeostasis, magnesium ion transmembrane transport, cell death, signal transduction, autophagy, and homeostasis. It localizes to the vCLAMP, fungal-type vacuole membrane, plasmalemma, and cytoplasm. MoMNR2 is linked to blast disease in rice (Oryza sativa). The gene is associated with numerous phenotypes including decreased spore germination, increased apoptosis, altered cell cycle progression, increased invasive growth, decreased UV and X-ray resistance, increased metal resistance, and abnormal vacuolar distribution. Related genes in other species connect the family to calcium sensitivity.