ABCA — Magnaporthe oryzae 70-15

Summary

MGG_10410 (MoABCA) encodes a pleiotropic drug resistance protein 1, a member of the ABCG transporter family with ATP hydrolase activity and ATP binding. The gene is associated with phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine floppase activities, as well as xenobiotic detoxification via transmembrane export across the plasma membrane. MoABCA is associated with appressorium formation, stimulus detection, protein dephosphorylation, patulin anabolism, hypersensitivity, cell death, and DNA repair. The protein localizes to the plasma membrane, vacuolar membrane, and extracellular vesicles. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, delayed mitophagy, and altered replicative and chronological lifespan. Studies of related genes in other species link the family to vacuolar transport, endocytosis, and nutrient uptake.