BCR1 — Magnaporthe oryzae 70-15

Summary

MGG_11201 (BCR1) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a carbon catabolite repressor with a Znf_C2H2-type domain and DNA-binding transcription factor activity. The gene is associated with carbon catabolite repression, regulation of carbon utilization, and downregulation of transcription by glucose. It is linked to appressorium formation and maturation, melanin anabolism, the MAPK cascade, and asexual reproduction. Associations also include long-chain fatty acid, triglyceride, and chitin breakdown, the glyoxylate cycle, and the oxidative pentose pathway. The product localizes to both the cytoplasm and nucleus. Phenotypic associations include abnormal pseudohyphal growth, decreased nitrogen and iron utilization, altered UV resistance, and defects in cell cycle progression, meiosis, and chromosome segregation. Studies of related genes in other species link the family to reduced virulence and hyperosmotic stress resistance.