OTA — Magnaporthe oryzae 70-15

Summary

MoOTA (MGG_11934) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a pyridoxal phosphate-dependent aminotransferase with L-ornithine transaminase and N2-acetylornithine 5-aminotransferase activities (EC 2.6.1.11). The gene is associated with ornithine metabolism, the urea cycle, arginine anabolism, L-proline biosynthesis, pigmentation, sexual reproduction, and hyphal growth. The product localises to the mitochondrial lumen, cytoplasm, cytosol, and nucleus. Phenotypic associations include altered cell cycle progression, endocytosis, autophagy, biofilm formation, flocculation, nutrient uptake and utilisation, osmotic stress resistance, and abnormal colony appearance, actin cytoskeleton morphology, and chromosome segregation. Studies of related genes in other species link the family to filamentous growth, thermotolerance, replicative lifespan, and protein content.