RAS2 — Magnaporthe oryzae 70-15

Summary

MGG_12077 (RAS2) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a Ras protein let-60, a member of the small GTPase Ras-type family with GTPase activity, GTP binding, and G protein activity. The gene is associated with the cAMP/PKA signaling cassette, Ras protein signal transduction, and protein farnesylation. It is linked to appressorium formation, regulation of conidium formation, cell adhesion involved in single-species biofilm formation, and cell-abiotic substrate adhesion. RAS2 is associated with filamentous growth in response to heat and chemical stimuli, phenotypic switching, upregulation of apoptosis, and mitigation of host defenses by symbiont. The encoded protein localizes to the plasmalemma and membrane. Related genes in other species are linked to reduced virulence.