ACP1 — Magnaporthe oryzae 70-15

Summary

MoACP1 (MGG_12818) on chromosome 4 of Magnaporthe oryzae 70-15 encodes an F-actin capping protein alpha subunit, belonging to the CapZ alpha family. The gene product binds F-actin and is a component of the F-actin capping protein complex, localising to the cortical cytoskeleton, actin patches, cellular bud tip, and the mitotic actomyosin contractile ring. MoACP1 is associated with barbed-end actin filament capping, actin cytoskeleton organisation, actin fusion focus formation, cortical patch organisation, and contractile ring assembly and contraction. It has been linked to appressorium formation, host invasion, invasive growth, morphogenesis, melanin anabolism, secretion, endocytosis, vacuolar transport, and regulation of growth. Associations with rice blast and barley have been noted. Studies of related genes in other species link the family to oxidative stress response and altered protein secretion, budding pattern, and autophagy.