PIK1 — Magnaporthe oryzae 70-15

Summary

MGG_12862 (MoPIK1, PIK1) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a phosphatidylinositol kinase with both PI3K and PI4K activities (EC 2.7.1.67), possessing protein kinase activity and ATP binding. The gene is associated with phosphoinositide signaling, PI(3)P and PI4P biosynthesis, plasma membrane-to-endosome transport, Golgi-to-plasma membrane protein transport, microlipophagy, protein localization to the vacuole, iron ion membrane transport and homeostasis, cellular responses to nitrogen and potassium starvation, immune evasion, and ascospore-type prospore assembly. It localizes to phosphatidylinositol 3-kinase complexes, the nucleus-vacuole junction, trans-Golgi network membrane, pre-autophagosomal structure, endosome and peroxisome membranes. Phenotypic associations include abnormal spore germination, delayed protein secretion and vacuolar transport, absent osmotic stress resistance and micronucleophagy, decreased cell cycle progression and cell death, and increased nutrient uptake.