PST1 — Magnaporthe oryzae 70-15

Summary

MGG_13498 (PST1) in Magnaporthe oryzae 70-15 encodes a Sin3-like protein containing a histone deacetylase interacting domain, annotated as a transcription corepressor with bridging and binding activities. It is associated with chromatin silencing, centromeric silencing, regulation of autophagy, non-homologous end joining, cell division, and both positive and negative regulation of transcription by RNA polymerase II. The gene product localizes to the nucleus, cytosol, chromatin, centric heterochromatin, and the Clr6-LE complex. Phenotypic associations include increased virulence, altered cell cycle progression, abnormal mating type switching, delayed mitophagy, increased nutrient uptake, and changes in nuclear size and export. Related genes in other species link it to the Rpd3S and Rpd3C(L) complexes, as well as to pH response.