GLN1 — Magnaporthe oryzae 70-15

Summary

MGG_14279 (MoGLN1) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a glutamine synthetase (EC 6.3.1.2) with glutamine synthetase activity and ATP binding, containing conserved Gln_synth_N and catalytic domains. The gene is associated with the ammonia assimilation cycle, appressorium formation, autolysis, TOR signaling, and localizes to the cytoplasm and nuclear periphery. It is linked to numerous phenotypes including decreased invasive growth, abnormal autophagy, absent mitophagy and endocytosis, increased vegetative growth, decreased osmotic stress resistance, abnormal cell cycle progression, and altered nutrient utilization. MoGLN1 is also connected to the ISR1 gene and has been studied in relation to blast disease on rice (Oryza sativa) and barley (Hordeum vulgare). Studies of glutamine synthetase family members in other fungi link the family to unaffected pathogenicity, though this has not been established for MoGLN1 itself.