ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_14400) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a P-glycoprotein 5, an ABC-type oligopeptide transporter with ATP hydrolase activity and ATP binding. It is associated with xenobiotic detoxification via transmembrane export, oligopeptide export from the mitochondrion, host invasion, invasive growth, morphogenesis, secondary metabolism, autophagy, cell wall biogenesis, and siRNA-mediated post-transcriptional gene silencing. The protein localises to the fungal-type vacuole, mitochondrial inner membrane, and plasmalemma. Phenotypic associations include altered vacuolar morphology and distribution, decreased endocytosis, abnormal cell cycle progression, increased pexophagy, and altered stress resistance. Related genes in other species include MDR2, which is linked to phospholipid export.