CUL3 — Magnaporthe oryzae 70-15

Summary

MGG_14763 (MoCUL3) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a cullin-4B protein, a scaffold component of ubiquitin ligase complexes. The gene is associated with ubiquitin ligase complex scaffold activity, IP6 binding, and ubiquitin ligase binding. It is linked to protein ubiquitination, SCF-dependent proteasomal ubiquitin-dependent protein breakdown, DNA damage response, cell death, cell division, and DNA-dependent transcription. MoCUL3 is connected to the CLRC complex, Cul4-RING E3 ubiquitin ligase complex, and nuclear SCF complex, localising to the nucleus, cytosol, and heterochromatin regions including centric, subtelomeric, and mating-type region heterochromatin. Phenotypic associations include decreased spore germination, abnormal sporulation, increased apoptosis, increased mitotic recombination, decreased UV and ionizing radiation resistance, increased cold sensitivity, increased stress resistance, decreased telomere length, and altered carbon source utilisation.