IMP1 — Magnaporthe oryzae 70-15

Summary

MoIMP1 (MGG_15072) on chromosome 2 of Magnaporthe oryzae 70-15 encodes an importin subunit alpha, a member of the importin-alpha family that contains an IBB domain and armadillo repeats. The encoded protein has nuclear import signal receptor activity and NLS-binding molecular function, and is associated with NLS-bearing substrate import into the nucleus, mitotic nuclear pore complex disassembly, and regulation of mitotic nuclear envelope breakdown. It is linked to protein localization to membrane rafts, NVJ assembly, and multiple autophagy-related processes including lipophagy, ribophagy, and pexophagy. The gene is associated with cell cycle progression, cytokinesis, chromosome segregation, sporulation, vacuole inheritance, homotypic vacuole fusion, sumoylation, and pH reduction. Phenotypic associations include altered cell cycle progression through G1/S and G2/M transitions, delayed cytokinesis, increased sporulation, abnormal nuclear import and export, abnormal chronological lifespan, and increased hydrostatic pressure resistance.