ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_15334) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a multidrug resistance protein 11, an ABC-type transporter with ATP-binding and hydrolase activity. The gene is associated with xenobiotic detoxification via transmembrane export, oligopeptide export from the mitochondrion, and response to antibiotics. It has been linked to host invasion, invasive growth, morphogenesis, cell wall biogenesis, autophagy, secondary metabolism, and signal transduction. Localisation evidence connects the product to the fungal vacuole, mitochondrial inner membrane, and plasma membrane. Phenotypic associations include altered vacuolar morphology, decreased endocytosis, abnormal cell cycle progression, increased pexophagy, and changes in osmotic and oxidative stress resistance.