COX6 — Magnaporthe oryzae 70-15

Summary

MGG_15895 (MoCOX6) encodes a cytochrome c oxidase subunit 5A/6 family protein with cytochrome-c oxidase activity and metal binding, localizing to the mitochondrial inner membrane as part of respiratory chain complex IV. The gene is associated with mitochondrial electron transport, cellular respiration, proton transmembrane transport, autophagy, mitophagy, and cellular homeostasis. MoCOX6 is linked to numerous phenotypes including absent vegetative growth, abnormal sporulation, decreased apoptosis and thermotolerance, increased mitophagy and biofilm formation, altered cell cycle progression through G1, S, and G2/M phases, decreased alkaline pH and hydrostatic pressure resistance, and abnormal carbon and nitrogen source utilization. The gene is also associated with mitochondrial genome maintenance, respiratory metabolism, and petite-negative status. Studies of related genes in other species link the COX6 family to oxidative stress response and hyperosmotic stress resistance.