KNS1 — Magnaporthe oryzae 70-15

Summary

MGG_16904 (MoKNS1) in Magnaporthe oryzae 70-15 encodes a dual-specificity kinase (EC 2.7.12.1) with protein serine/threonine and tyrosine kinase activities, ATP binding, and phosphatidylinositol phosphate binding. It is associated with the stress-activated MAPK cascade, autophagic cell death, regulation of RNA splicing, osmolarity sensing, and negative regulation of the cell integrity MAPK cascade and G1/S transition. The gene is linked to cell cycle progression, including G2 phase duration and mitotic cytokinesis site selection, as well as bipolar cell polarity establishment. Phenotypic associations include altered thermotolerance, sporulation, meiotic recombination, UV and ionic stress resistance, and decreased pheromone sensitivity. The protein localizes to the cell tip, mitotic actomyosin contractile ring, spindle pole body, and mitochondria. Related genes in other species are linked to reduced virulence and oxidative stress response.