tlh1 — Magnaporthe oryzae 70-15

Summary

MGG_16997 (tlh1) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a C2H2-type domain-containing protein with four-way junction helicase activity, 3'-5' DNA helicase activity, nucleic acid binding, ATP hydrolase activity, DNA binding, zinc binding, and ATP binding. The protein contains OrsD, DEAD/DEAH_box_helicase, helicase ATP-binding, C2H2 zinc finger, and P-loop NTPase domains. It is associated with telomere maintenance via recombination, homologous recombination, DNA recombination, DNA repair, sexual reproduction, mating, and digestion. The gene product localizes to the chromosome, telomeric repeat region, cytoplasm, and nucleus. Studies of related genes in other species link the family to DNA 3'-5' helicase function and EC 5.6.2.4.