SEC11 — Magnaporthe oryzae 70-15

Summary

MGG_17533 (SEC11, MoSEC11) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a protein with a Peptidase_S26 domain and serine-type endopeptidase activity (EC 3.4.21.89), annotated with signal peptidase activity. The protein is localised to the signal peptidase complex. SEC11 is associated with protein secretion, ER targeting, and protease activity. Phenotypic associations link the gene to abnormal colony appearance, decreased biofilm formation, absent invasive growth, decreased vegetative growth, abnormal cell cycle progression, decreased stress resistance, and altered chemical compound accumulation. Additional associations include abnormal peroxisomal, nuclear, and vacuolar morphology, decreased endocytosis, and changes in RNA and protein accumulation. Studies of related genes in other species connect the family to increased chemical compound excretion and protein accumulation.