PEX4 — Magnaporthe oryzae 70-15

Summary

MGG_00180 (MoPEX4, also known as UBC16) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a protein with ubiquitin conjugating enzyme activity and ubiquitin-protein transferase activity, belonging to the UBC and UBQ-conjugating enzyme/RWD families. It is associated with peroxisome membrane biogenesis, peroxisome matrix protein import and receptor recycling, and peroxisome organization. The gene is linked to negative regulation of the SREBP signaling pathway, stress-induced homeostatically regulated protein degradation, the N-end rule pathway, and cellular response to unfolded protein. It localizes to the peroxisome membrane, cytoplasm, nucleus, and several ubiquitin ligase complexes. Phenotypic associations include absent peroxisomal transport and morphology, decreased chitin deposition, abnormal cell cycle progression, reduced filamentous and invasive growth, and increased mutation frequency. Studies of related genes in other species link the family to reduced virulence.