DCI1 — Magnaporthe oryzae 70-15

Summary

MGG_00359 (MoDCI1) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a protein with a ClpP/crotonase-like domain superfamily and enoyl-CoA hydratase/isomerase domain, possessing delta3,5-delta2,4-dienoyl-CoA isomerase and delta3-delta2 enoyl-CoA isomerase activities (EC 5.3.3.21). The gene is associated with fatty acid beta-oxidation and breakdown, and with hyphal growth. Its product localises to the peroxisomal lumen and cytosol. MoDCI1 is linked to abnormal vegetative growth, decreased biofilm formation, altered carbon source utilisation, increased heat sensitivity, and changes in chronological lifespan and competitive fitness. Peroxisomal transport and morphology are also affected. Related genes in other species connect the family to peroxisomal fatty acid oxidation.