CKB1 — Magnaporthe oryzae 70-15

Summary

MoCKB1 (MGG_00446) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a protein containing a casein kinase II regulatory subunit N-terminal domain and belonging to the casein kinase II beta-like family. The encoded protein is associated with protein serine/threonine kinase inhibitor activity, protein kinase regulator activity, and protein kinase activity. MoCKB1 is associated with appressorium formation, signal transduction, DNA damage response, cell cycle modulation, and regulation of transcription by RNA polymerases I, II, and III, as well as positive regulation of chromatin silencing at centromeres and silent mating-type cassettes. The gene is linked to blast disease in rice (Oryza sativa). Phenotypic associations include increased thermotolerance, delayed vegetative growth, absent biofilm formation, increased cell death, abnormal telomere length, and numerous cell cycle progression defects including arrest and increased duration of multiple phases.