DBP2 — Magnaporthe oryzae 70-15

Summary

MoDBP2 (DBP2) of Magnaporthe oryzae 70-15 on chromosome 5 encodes a DEAD-box RNA helicase with RNA helicase activity, RNA binding, ATP hydrolase activity, and ATP binding. The gene is associated with rRNA processing, sexual reproduction, mating, and digestion, and its product localises to the nucleolus. Associations with numerous phenotypes include abnormal mitotic recombination, decreased mating-type switching, absent sporulation efficiency, delayed vegetative and exponential-phase growth, increased thermotolerance and gamma-ray resistance, altered cell cycle progression (including increased S-phase rate, premature G1/S transition, and delayed anaphase), increased fermentative growth, and altered carbon source utilisation. Studies of related genes in other species link the family to oxidative stress response and lethal phenotypes, but these associations are not established for MoDBP2 itself.