RFA1 — Magnaporthe oryzae 70-15

Summary

MGG_00685 (MoRFA1) on chromosome 5 of Magnaporthe oryzae encodes a protein with Rep_factor-A and OB-fold domains. It exhibits ssDNA binding, damaged DNA binding, telomeric repeat binding, and telomerase RNA binding activities. MoRFA1 is associated with nuclear DNA replication, telomere maintenance via telomerase, nucleotide excision repair, homologous recombination, mitotic recombination, regulation of ribosome biogenesis, autophagy, and appressorium formation. The protein localises to chromatin, telomeric regions, sites of DNA damage, and the RPA complex. Associations with cell cycle progression, sporulation, and replicative lifespan have been reported. Studies of related genes in other species connect it to DNA repair and genome stability.