GID1 — Magnaporthe oryzae 70-15

Summary

MoGID1 (MGG_00753) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a RanBPM family protein containing SPRY, CTLH/CRA, and LisH domains, and is annotated as a ubiquitin ligase substrate adaptor with small GTPase binding and protein-bridging activity. The gene is associated with asexual reproduction, morphogenesis, cytoskeleton organization, homologous recombination, protein transport, and downregulation of gluconeogenesis. It is linked to protein-vacuolar targeting during ubiquitin-dependent breakdown via the MVB pathway and the proteasomal pathway. The product localizes to the GID complex, endosome membrane, vacuolar membrane, fungal-type vacuole, cytoplasm, and nucleus. MoGID1 has been associated with blast disease in rice (Oryza sativa). Related genes in other species link the family to ubiquitin-signaling pathway regulation.