FOR — Magnaporthe oryzae 70-15

Summary

MoFOR (MGG_00923) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a serine hydroxymethyltransferase (SHMT) with glycine hydroxymethyltransferase activity, pyridoxal phosphate binding, and methyltransferase activity. This enzyme is associated with tetrahydrofolate interconversion and metabolism, mRNA modification, and jasmonic acid anabolism. The gene is associated with host invasion, innate immunity, immune response, autophagy, ER-phagy, regulation of autophagy, secretion, endocytosis, morphogenesis, lipid metabolism, methylation, and homeostasis. It localizes to mitochondria, cytoplasm, cytosol, and the fungal biofilm matrix. Associations with turgor pressure and numerous cell cycle, meiotic, and metabolic phenotypes have been noted, though these are not established in M. oryzae itself. Studies of related genes in other species link the SHM family to nutrient utilization.