MES1 — Magnaporthe oryzae 70-15

Summary

MGG_01046 (MoMES1) on chromosome 5 of Magnaporthe oryzae 70-15 encodes a methionine-tRNA ligase (EC 6.1.1.10) with methionine-tRNA ligase activity, ATP binding, and sequence-specific mRNA binding. The protein belongs to the MetRS and methionyl/leucyl-tRNA synthase families and localises to the cytosol, mitochondria, mitochondrial lumen, stress granules, and the multisynthetase complex. MoMES1 is associated with methionyl-tRNA aminoacylation, cytoplasmic and mitochondrial translation, programmed cell death, innate immunity, and immune response. The gene has been linked to numerous phenotypes including decreased viability, abnormal cell cycle progression, increased cell size, altered sporulation, reduced filamentous and invasive growth, increased stress resistance and cold sensitivity, and abnormal chromosome maintenance. Studies of related genes in other species connect the family to G1 cell-cycle control, pseudohyphal growth, and telomere maintenance.