KIN1 — Magnaporthe oryzae 70-15

Summary

MGG_01279 (MoKIN1) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a serine/threonine protein kinase with protein kinase A activity, containing a KA1 domain and a kinase-like domain superfamily. The gene is associated with mitotic cytokinesis site selection, positive regulation of cell cycle switching from mitotic to meiotic, negative regulation of cytoplasmic translation, and negative regulation of inositol phosphate biosynthesis. It is linked to mycose catabolism, single-species surface biofilm formation, regulation of invasive growth in response to glucose limitation, asexual reproduction, and upregulation of gluconeogenesis. Associations also include CAMKK-AMPK signaling, positive regulation of pseudohyphal growth, fungal-type cell wall assembly, plasma membrane organization, and cell growth mode switching. The gene is connected to blast disease in rice (Oryza sativa). Studies of related genes in other species link the family to oxidative stress response and loss of pathogenicity.