CAF5 — Magnaporthe oryzae 70-15

Summary

MoCAF5 (MGG_01511) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a benomyl/methotrexate resistance protein belonging to the major facilitator superfamily (MFS) of transporters. The protein exhibits transmembrane transporter activity for fluconazole, xenobiotics, and spermine, and is associated with calcium ion homeostasis, responses to antibiotics and xenobiotic stimuli, spermidine and spermine transport, immune response, oxidative stress, and xenobiotic detoxification at the plasma membrane. It localises to the peroxisome membrane, Golgi, ER, and plasmalemma. The gene is linked to numerous phenotypes including decreased cell cycle progression in S phase, increased survival in stationary phase, abnormal budding and cell shape, increased filamentous growth, decreased sporulation efficiency and viability, altered stress resistance, and increased mutation frequency and transposable element transposition. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.