OBR1 — Magnaporthe oryzae 70-15

Summary

MoOBR1 (MGG_01569) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a minor allergen Alt a 7 family protein with flavoprotein WrbA-like and flavodoxin domains, and exhibits NAD(P)H dehydrogenase (quinone) activity, 2-hydroxy-1,4-benzoquinone reductase activity, and FMN binding. The gene is associated with appressorium formation, cellular response to oxidative stress, and localisation to the eisosome, hyphal cell wall, fungal biofilm matrix, plasma membrane, cytoplasm, and nucleus. It is linked to blast disease in rice and to oxidative stress response. Phenotypic associations include abnormal cell cycle progression, increased sporulation, altered UV resistance, increased cell death, and defects in chromosome segregation and pexophagy. Studies of related genes in other species connect the family to loss of pathogenicity and decreased stationary-phase survival.