HOG1 — Magnaporthe oryzae 70-15

Summary

MGG_01822 (HOG1) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a mitogen-activated protein kinase of the MAPK_Sty1/Hog1 and p38-like families, with protein serine/threonine kinase activity (EC 2.7.11.24) and ATP binding. The gene is associated with the stress-activated MAPK cascade, the cellular HOG response, osmotic and salt responses, glycerol metabolism, pigmentation, vacuole fusion, cytokinesis, hyphal growth, appressorium formation, and host invasion. It is linked to responses to heat and oxidative stress, and to phosphoglyceride metabolism. The encoded protein localises to the cytoplasm and nucleus. Associations with blast disease in rice and with Oryza sativa have been noted. Related genes in other species are linked to turgor pressure, germination rate, calcium and acid sensitivity, and altered virulence.