ABC2 — Magnaporthe oryzae 70-15

Summary

MoABC2 (MGG_02348) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a multidrug resistance protein 3, an ABC-type transporter with ATP-binding cassette domains and ATP hydrolase activity. It is associated with xenobiotic detoxification via transmembrane export, oligopeptide export from mitochondria, siRNA-mediated post-transcriptional gene silencing, host invasion, invasive growth, morphogenesis, autophagy, secondary metabolism, cell wall biogenesis, and response to antibiotics. The protein localises to the fungal vacuole, mitochondrial inner membrane, and plasma membrane. Phenotypic associations include abnormal vacuolar morphology and distribution, decreased endocytosis, altered cell cycle progression, increased pexophagy, and changes in osmotic and oxidative stress resistance.