TGL1 — Magnaporthe oryzae 70-15

Summary

MoTGL1 (MGG_02622) on chromosome 7 of Magnaporthe oryzae 70-15 encodes a protein with an alpha/beta hydrolase domain and sterol esterase activity. The gene is associated with appressorium formation and maturation, lipolysis, and the metabolism of glycerol, ergosterol, and sterols. It is linked to lipid A biosynthesis and localises to the fungal vacuole, Golgi, membrane, and cytoplasm. Associations with rice blast disease and the host Oryza sativa are observed. The gene has been connected to numerous phenotypes including decreased adhesion, filamentous growth, and sporulation; abnormal bud morphology, cell cycle progression, and meiosis; increased biofilm formation and telomere length; and altered turgor pressure, nutrient uptake, and stress resistance. Related genes in other species link the family to triacylglycerol lipase and sterol esterase activities.